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Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li
《医学前沿(英文)》 2019年 第13卷 第4期 页码 471-481 doi: 10.1007/s11684-019-0686-8
XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
《医学前沿(英文)》 2007年 第1卷 第3期 页码 316-319 doi: 10.1007/s11684-007-0061-z
关键词: significant difference occurrence hemoglobin risperidone treatment abnormal
中药生物活性成分对糖脂代谢紊乱疾病的治疗作用和机制 Review
张莹, 鞠佳明, 焦磊, 杨宝峰
《工程(英文)》 2023年 第29卷 第10期 页码 73-82 doi: 10.1016/j.eng.2023.03.004
胆固醇和葡萄糖稳态异常在心血管疾病、脑血管疾病、中枢神经系统疾病和癌症等多种疾病的发生发展中起着至关重要的作用。 越来越多的研究表明,体内脂肪堆积过多与2型糖尿病或胰岛素抵抗有关,高胆固醇和高血糖将加重上述疾病的发展进程。因此,稳定患者的血脂和血糖水平是改善心脑血管和中枢神经系统疾病患者症状的主要策略。中药(CHM)在中国已有两千多年的历史,建立了独特的中医理论,积累了丰富的临床经验。此外,中药在国内外广泛应用于心脑血管疾病的治疗和预防,具有防治高脂血症、糖尿病和高血压等疾病的优势。然而,中药在西方国家的使用仍然相当有限,部分原因是对其多种复杂成分的了解不完整,药理机制不确定。本文就中药生物活性成分及其制剂治疗高脂血症和高血糖症的作用、分子机制和临床研究进展进行综述和讨论。
关键词: Chinese herbal medicines Hyperlipidemia Hyperglycemia Cardiovascular and cerebrovascular diseases
Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1866-1878 doi: 10.1007/s11705-023-2340-x
关键词: implantable glucose biosensor anti-biofouling continuous glucose monitoring immune responses
Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
《医学前沿(英文)》 2020年 第14卷 第4期 页码 498-505 doi: 10.1007/s11684-020-0791-8
关键词: disorders of sex development (DSD) intelligent diagnosis dynamic uncertain causality graph
《医学前沿(英文)》 2023年 第17卷 第1期 页码 68-74 doi: 10.1007/s11684-022-0955-9
关键词: complexity of glucose time series continuous glucose monitoring impaired glucose regulation insulin secretion and sensitivity refined composite multi-scale entropy
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1593-1607 doi: 10.1007/s11705-023-2348-2
关键词: cellulose nanofibril aerogel nickel-cobalt layered double hydroxide polypyrrole nonenzymatic glucose sensor
《医学前沿(英文)》 2021年 第15卷 第3期 页码 460-471 doi: 10.1007/s11684-021-0861-6
关键词: low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose
Therapeutic effects of thalidomide in hematologic disorders: a review
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 290-300 doi: 10.1007/s11684-013-0277-z
The extensive autoimmune, anti-inflammatory, and anticancer applications of thalidomide have inspired a growing number of studies and clinical trials. As an inexpensive agent with relatively low toxicity, thalidomide is regarded as a promising therapeutic candidate, especially for malignant diseases. We review its therapeutic effects in hematology, including those on multiple myeloma, Waldenstroem macroglobulinemia, lymphoma, mantle-cell lymphoma, myelodysplastic syndrome, hereditary hemorrhagic telangiectasia, and graft-versus-host disease. Most studies have shown satisfactory results, although several have reported the opposite. Aside from optimal outcomes, the toxicities and adverse effects of thalidomide should also be examined. The current work includes a discussion of the mechanisms through which the novel biological effects of thalidomide occur, although more studies should be devoted to this aspect. With appropriate safeguards, thalidomide may benefit patients suffering from a broad variety of disorders, particularly refractory and resistant diseases.
Mesenchymal stem cells and immune disorders: from basic science to clinical transition
Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao
《医学前沿(英文)》 2019年 第13卷 第2期 页码 138-151 doi: 10.1007/s11684-018-0627-y
关键词: mesenchymal stem cell clinical transition immune disorders
《医学前沿(英文)》 doi: 10.1007/s11684-023-1006-x
关键词: neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 307-318 doi: 10.1007/s11684-017-0547-2
Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of extract (GBE) against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel rat cortical capillary endothelial cell-astrocyte-neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B (GB), against oxygen–glucose deprivation/reoxygenation and glucose (OGD/R) injury. In this model, rat cortical capillary endothelial cells, astrocytes, and neurons were cocultured so that they could be synchronously observed in the same system. Pretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibited the cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury. Furthermore, GBE or GB pretreatment enhanced the transendothelial electrical resistance of capillary endothelial monolayers, reduced the endothelial permeability coefficients for sodium fluorescein (Na-F), and increased the expression levels of tight junction proteins, namely, ZO-1 and occludin, in endothelial cells. Results demonstrated the preventive effects of GBE on neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury ; thus, GBE could be used as an effective neuroprotective agent for AIS/reperfusion, with GB as one of its significant constituents.
关键词: acute ischemic stroke Ginkgo bilobaextract Ginkgolide B network model neuroprotection
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 70-78 doi: 10.1007/s11684-020-0749-x
关键词: myocardial infarction percutaneous coronary intervention diabetes mellitus fasting glucose heart failure
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《医学前沿(英文)》 2014年 第8卷 第4期 页码 477-483 doi: 10.1007/s11684-014-0346-y
The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35–75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; P=0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20--2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.
关键词: dyslipidemia plasma lipids plasma fasting glucose impaired fasting glucose non-diabetes
TANG Zhongzhi, LI Junyao, YANG Jianhong
《医学前沿(英文)》 2008年 第2卷 第2期 页码 178-181 doi: 10.1007/s11684-008-0033-y
标题 作者 时间 类型 操作
Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders
Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li
期刊论文
Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic
XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
期刊论文
Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of
Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
期刊论文
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlatedwith deteriorating glucose regulation
期刊论文
decorated with polypyrrole and nickel-cobalt layered double hydroxide for high-performance nonenzymatic glucose
期刊论文
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized
期刊论文
Mesenchymal stem cells and immune disorders: from basic science to clinical transition
Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao
期刊论文
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function
期刊论文
Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model
null
期刊论文
Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
期刊论文
Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic
null
期刊论文